Exclamation point

We are still accepting patients. Read about our COVID-19 statement here.

We are still accepting patients. Read about our COVID-19 statement here.

info@dvcstem.com

1 (877) DVC STEM

Stem Cell Therapy for Parkinson's Disease in 2020

Stem cell therapy may be a viable treatment option for Parkinson's Disease. Mesenchymal stem cells have the ability to target and reduce inflammation which may help neurological conditions.

Reading time: Under 5 minutes

David Lyons

Guest contributor

Jun 8, 2020

Louis A. Cona, MD

Medical Director of DVC Stem

Stem cell therapy clinic in Grand Cayman

Updated:

Monday, June 8, 2020

Explaining the relationship between stem cell therapy and Parkinson's.

Stem Cell Therapy for Parkinson's Disease

Stem cell therapy may have the benefit of replacing and repairing damaged dopamine-producing nerve cells within the brain. This has already been found in a study conducted by Neelam K.Venkataramana and colleagues. Seven PD patients aged 22 to 62 years with a mean duration of disease 14.7 ± 7.56 years were enrolled to participate in the prospective, uncontrolled, pilot study of single-dose, unilateral transplantation of autologous bone-marrow-derived mesenchymal stem cells (BM-MSCs). Patients were followed up for 36 months post-transplant, 3 of the 7 patients showed significant improvement in their Unified Parkinson's Disease Rating Scale (UPDRS) of 38%.

According to Medical News Today "Currently, the most common therapy uses the drug levodopa to stimulate dopamine production in certain neurons associated with motor skills. These dopaminergic neurons are situated in the nigrostriatal pathway which is a brain circuit that connects neurons in the substantia nigra pars compacta with the dorsal striatum. However, levodopa has a wide array of side effects, from physiological to psychological ones. Also, in the long-term, the benefits of such dopamine-regulating drugs are limited. So, scientists must come up with more effective strategies for repairing the brain damage that Parkinson's disease causes."

At DVC Stem we are seeing promising results with Cord Tissue-Derived Mesenchymal Stem Cells, cell numbers and viability has largely increased making the treatment more effective than Bone Marrow-Derived treatments that were used in the early 2010s. The development of these advanced cellular therapies is making it possible to combat the progression of the disease without the resulting motor complications.

What is Parkinson's Disease (PD)?

Parkinson's Disease is a degenerative nervous system condition that affects one's movement. Symptoms often start quite gradually, with minor issues such as small tremors within the extremities (hands). Currently, there is no cure for Parkinson's Disease (PD) but certain medications do have the capacity to help manage symptoms. Some doctors may also recommend surgery to address certain symptoms, which involves regulating certain areas of the brain.

What are the symptoms of Parkinson's Disease (PD)?

Parkinson's DIsease (PD) can include a variety of symptoms that vary in severity and type amongst the affected population. Early signs of the condition can sometimes go unnoticed but as the disease progresses one can expect these symptoms:

  • Difficulty speaking
  • Difficulty writing
  • Loss of automatic movements (Characterized by the inability to blink, smile or perform common body language practices)
  • Slowed overall movement (making everyday tasks more time consuming)
  • Muscle stiffness
  • Tremors or shaking

What causes Parkinson's Disease?

Parkinson's Disease is caused by a loss (or deterioration) of nerve cells in the brain. This loss of nerve cells within the brain results in a reduced amount of dopamine being created which acts as a messenger between the parts of your brain that control voluntary and involuntary movement. Therefore without that vital connection, your brain starts losing the ability to effectively control movement. Currently, it is unknown what causes the deterioration of nerve cells associated with Parkinson's Disease (PD). Currently, it is believed that both environmental factors, as well as genetic factors, may play a role in the loss of nerve cells.

Parkinson's Disease is a lifelong condition that can greatly impair the ability of one's daily functions. Traditional treatments only address the symptoms of the condition, but researchers are excited about the possibilities of certain gene therapies and stem cell therapy, which may have the ability to reverse damage and halt the progression of the disease.

So what are stem cells?

Stem cells are cells that have not yet specialized in the body, meaning they have not grown to a particular type of cell with a specific function (e.g. muscle cell, skin cell, etc). A stem cell can become many different cell types in the human body. The process of stem cells become new types of cells is called differentiation. This process is the most important aspect of stem cell therapies, as the cells become the type of cells required for your body to heal. Stem cells are also self-replicating. This allows them to multiply into identical copies of the stem cells that have already gone through differentiation in the body. For example, if stem cells were used to treat a neurological injury, cells administered during treatment could become nerve cells, and then replicate to create exponentially more nerve cells on their own. This drastically increases the effectiveness of stem cell treatments over time.

Stem Cells for Parkinson's Disease are safe

According the Venkataraman and colleagues, "A subjective improvement was found in symptoms like facial expression, gait, and freezing episodes; 2 patients have significantly reduced the dosages of PD medicine. These results indicate that our protocol seems to be safe, and no serious adverse events occurred after stem-cell transplantation in PD patients."

As stated in a 2005 study held by Brian Snyder,

Stem cells offer the potential to provide a virtually unlimited supply of optimized dopaminergic neurons that can provide enhanced benefits in comparison to fetal mesencephalic transplants. Stem cells have now been shown to be capable of differentiating into dopamine neurons that provide benefits following transplantation in animal models of Parkinson's disease.

Learn more about DVC Stem's protocol for Parkinson's Disease (PD) here: https://www.dvcstem.com/conditions/parkinsons

References:

(1) Venkataramana, N. K., Kumar, S. K. V., Balaraju, S., Radhakrishnan, R. C., Bansal, A., Dixit, A., … Totey, S. M. (2009, August 6). Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease. Retrieved from https://www.sciencedirect.com/science/article/pii/S1931524409002205#!

(2) Unified Parkinson's Disease Rating Scale. (n.d.). Retrieved from https://www.sciencedirect.com/topics/medicine-and-dentistry/unified-parkinsons-disease-rating-scale

(3) Department of Neurosurgery Department of Neurology and Neuroscience. (n.d.). Stem cell treatment for Parkinson's disease: an update for... : Current Opinion in Neurology. Retrieved from https://journals.lww.com/co-neurology/Abstract/2005/08000/Stem_cell_treatment_for_Parkinson_s_disease__an.5.aspx

"Dr. Cona is a leading edge stem cell treatment physician"

Matthew Murry - MS Patient

2 DAYS POST TREATMENT

"Is the video I posted from this morning! My speech is so easy for me now, got easier throughout the day! I can talk like a NYer (fast) for the first time in years! Praise God!"

- Matthew Murry

EXCITING IMPROVEMENTS

Only 3 days after treatment, Matthew is now able to touch his nose with his eyes closed as well as touch his thumb and pinky together. Both of which he was previously unable to do before treatment.

We are excited to see his continued progress. His story will be updated here so keep an eye out!

Matthew showing his progress with mobility

Matthew Murry - 3 days post treatment

"This is exciting stuff, god bless"

Matthew Murry - MS Patient

2 WEEKS POST TREATMENT

Matthew experiences sensation in the bottom of his feet after receiving a simple nerve test.

His left foot did not experience any sensation or move at all, but what happened to his right foot is extremely exciting!

50 DAYS POST TREATMENT

Matthew is now able to lift his leg unassisted. He was previously unable to do so.

Matthew is experiencing the benefits of stem cell therapy first hand. You can view his progress video here.


Matthew showing some amazing mobility improvements.

Matthew Murry - 50 days post treatment

"Amazing progress from one of our MS patients Matthew Murray"

Louis A. Cona, MD - DVC Stem

3 MONTHS POST TREATMENT

Matthew is able to stand up with the assistance of stability bars.

David Lyons

Multiple Sclerosis

Although David Lyons was able to successfully fight Multiple Sclerosis through a strict regimen of diet and exercise, he wanted to ensure he was doing everything he could to stay fit. Multiple Sclerosis can be managed with treatment, but there is currently no cure for the disease. For that reason, David came to DVC Stem years ago to use the regenerative and anti-inflammatory attributes of stem cells to aid in his fight for fitness.

The positive results he experienced enabled David to stay strong in the gym, now into his 60s, and that is why he continues to support our clinic to this day.

Are you a candidate?

Complete our online application form to find out if you qualify for stem cell therapy.

APPLY FOR TREATMENT

About Our Medical DIrector

Louis A. Cona, MD

LOUIS A. CONA, MD

Dr. Cona has been performing stem cell therapy for over 10 years. He is a member of the World Academy of Anti-Aging Medicine (WAAAM). He is also a recognized member of the British Medical Association, the General Medical Council (UK), the Caribbean College of Family Physicians, and the American Academy of Family Physicians. He is the Medical Director for DVC Stem a world-renowned stem cell therapy clinic located in Grand Cayman.

Are you a candidate?

Complete our online application form to find out if you qualify for stem cell therapy.

APPLY FOR TREATMENT

Receive stem cell information via email

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.

CONTACT US

info@dvcstem.com

FOLLOW DVC STEM

Receive stem cell information via email

Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.