IRB-approved

Treatment Protocol

We are now accepting applicants for our patient-funded clinical study, The Effects of Cord Tissue Derived MSCs on the Treatment of Chronic Low Grade Inflammation, which is registered with Cayman Islands Government (Trial HPC/CTr/003).

UCT Derived Mesenchymal Stem Cells (MSCs)
mesenchymal stem cells
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Treatment
details.

Our IRB-approved protocol involves the intravenous (IV) infusion of 300 million culturally expanded human umbilical cord tissue-derived adult mesenchymal stem cells (MSCs).

Learn more about our protocol below

Protocol overview

Our Medical Director

Our Medical Director, Louis A. Cona, MD, is a pioneer in regenerative cell therapy, providing the first stem cell treatments in the Cayman Islands more than a decade ago. He continues to research alternative therapies for various medical conditions, and with IRB-approved clinical trials, has treated hundreds of patients for Multiple Sclerosis (MS), Parkinson's, Crohn's Disease, Chronic Low Grade Inflammation (which is part of the overall Aging Process), and many other degenerative conditions.

Louis A. Cona, MD is certified by the World Academy of Anti-Aging Medicine (WAAAM). He is an associate professor at St. Matthews School of Medicine, Deputy Chair of the Health Practice Commission Cayman Islands Government, past chairman of Medical & Dental Council of the Cayman Islands, Medical Director of the Strand Medical Centre, past president of Cayman Islands Medical & Dental Society. He is also a recognized member of the British Medical Association, the General Medical Council (UK), the Caribbean College of Family Physicians, and the American Academy of Family Physicians.

About

Our IRB-approved protocol consists of a two-day period including the intravenous (IV) transplant of 300 million umbilical cord tissue-derived Mesenchymal Stem Cells (MSCs), as well as a variety of therapies designed to aid in stem cell activation and potency (musculoskeletal rehabilitation, acupuncture, lymphatic massage).

Our protocol is minimally invasive to the patient and has very little downtime. There is typically a 1-2 hour rest and recuperation period immediately following the infusion.

Method of Administration

Our medical team administers the MSCs via intravenous injection. An IV line is inserted into the forearm and the cells are administered by hand into the line over the course of a few hours.

Our manual administration protocol helps to reduce temporary side effects and promote higher cell viability numbers, leading to greater treatment efficacy. The procedure is non-invasive and there is no pain associated with the injection of cells. The patient is directly supervised by our medical team throughout the entire procedure to ensure safety and comfort.

Treatment Schedule

We are an outpatient facility, this means that patients will only be in the clinic for the duration of the treatments during the day. Patients are responsible for booking their own travel & accommodation - we require all patients to stay in Grand Cayman for a minimum of 5 days.

Day 1: Arrival in Grand Cayman
Day 2: Complimentary therapies (half day)
Day 3: Mesenchymal stem cell infusion (full day)
Day 4: Follow-up physical (1-2 hours)
Day 5: Departure


The procedure is minimally invasive (single IV transfusion) and has very little downtime.

Efficacy Goals

The therapeutic uses of stem cells as a potential therapy for a variety of diseases has been immensely explored, the number of clinical trials conducted with Mesenchymal Stem Cells has increased exponentially over the past few years.

The stated primary goal of our protocol is the marked reduction in the levels of chronic and localized inflammation for an extended period of time.

Stem cells have a unique, intrinsic property that attracts them to inflammation in the body. Studies have shown that stem cells can regenerate damaged or diseased tissues, reduce inflammation and modulate the immune system promoting better health and quality of life.

Depending on the primary ailment or initial condition of the patient, the effects of stem cell therapy can lead to a reduction in harmful symptoms, stabalization of condition and a significant quality of life improvement.

Treatment Protocol Highlights:

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300M MSCs administered

Our protocol calls for the manual systemic (IV) administration of 300 million mesenchymal stem cells (MSCs).

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Pre-infusion Hydration Fluids

To ensure the body is hydrated and fully prepared for treatment.

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Detox Regime

We will guide you through the pre-treatment detox regime in order to prepare your body for optimal stem cell activation.

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Stem Cell Activation Therapies

Complimentary therapies aimed at preparing the body for an influx of mesenchymal stem cells.

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Fasting Recommendations

Prolonged fasting between 48–120 hours can activate pathways that enhance cellular resistance to toxins and stress.

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Concierge Onboarding Service

We have a professional team dedicated to ensuring the onboarding process is as smooth as possible.

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Minimally Invasive Treatment

There is no extraction process involved with our treatment & the cells are infused via a single IV line. Recovery time is roughly 1-2 hours.

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Handicap Accessible

Our facility, airport and partner resorts are fully handicap accessible. Additionally, our team can assist when needed if the patient is non-ambulatory.

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Improve Bodies Natural Healing Abilities

MSCs have potent immunomodulatory and anti-inflammatory properties without the negative side effects of traditional medications.

Our stem cell product

cGMP Quality
Mesenchymal Stem Cells

Adherence to the cGMP regulations assures the identity, strength, quality, and purity of our mesenchymal stem cell (MSC) product by requiring that our partner lab adequately controls manufacturing operations.

AriseHealth logoClinical Laboratory Improvement Amendment2020INC logoISO Certification

Cell product

Type of stem cells administered

Our protocol involves the systemic administration of 300 million culturally expanded Mesenchymal Stem Cells derived from American Association of Tissue Bank (AATB) certified suppliers of full term (>36 weeks), ethically donated human umbilical cords in the United States.

Umbilical cord tissue-derived mesenchymal stem cells (UC-MSCs) have the ability to become different cell types and have the greatest proliferation rate of other types of stem cells (adipose, bone marrow, etc). UC-MSCs are known to secrete growth factors, cytokines, and chemokines, improving different cell repair mechanisms.  These functions all assist the anti-inflammatory and immunomodulatory properties of MSCs.

Non-invasive cell product
The harvesting procedure of UC-MSCs is non-invasive as it does not require extraction from the patient.  The MSCs are taken directly from the Wharton's Jelly an area of an ethically donated human umbilical cord. UC-MSCs also have a high proliferative potential than other sources of stem cells meaning they expand in vitro more effectively allowing for greater efficiency when obtaining higher cell numbers.

Our partner lab

DVC Stem is partnered with an award-winning medical laboratory located in the United States, which is fully FDA registered, cGMP compliant, ISO 9001, and ISO 13485 certified. All of our cells are expanded using safe and standard protocols and are then flown overnight in sub-zero (-190° celsius) dewar containers directly to our clinic for treatment. To ensure maximum treatment effectiveness, all of our cells are ISCT tested for viability (% of live cells) prior to use.

Regulation & donor screening

Our partner lab in the United States only uses American Association of Tissue Bank (AATB) certified suppliers of full-term (>36 weeks), donated human umbilical cords. The selection of these donated tissues is extremely regulated and strict. The cords are tested for STDs, Hep A/B/C/D, TB, Zika virus, no history of cancer or chronic illness, no history of autoimmune diseases, no tattoos or piercings, no travel abroad with one year, no history of CJD, negative for HIV, negative for HTLV 1 AND 2, negative for SARS-COV2 and no history of drug or alcohol abuse.

After the tissue is vigorously screened and accepted, our lab uses a clinical-grade and award-winning proprietary culture medium to expand the stem cells out to roughly 300 million cells per treatment. Full international and domestic compliance & regulations are followed.

We only use umbilical cord tissue sourced from unvaccinated donors.

Cell Product Highlights:

vaccines

cGMP Quality Cells

Adherence to the cGMP regulations assures the identity, strength, quality, and purity of our mesenchymal stem cell (MSC) product by requiring that our partner lab adequately controls manufacturing operations.

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USA Sourced MSCs

DVC Stem is partnered with an award-winning medical laboratory located in the United States, which is fully FDA registered, cGMP compliant, ISO 9001, and ISO 13485 certified.

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Viability Testing Conducted

Cell viability assays are used to measure the physical and physiological health of cells in response to extracellular stimuli and ensure every patient receives the same dosage (300m MSCs).

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COA Authenticity

A Certificate of Analysis (COA) is a document that communicates the results of scientific tests done on the cells prior to infusion. The COA is created to ensure we comply with all all safety/efficacy regulations.

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ISCT Approved

The ISCT definition dictates that MSCs should have ≥95% surface marker expression, which we strictly follow.

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Immune-privileged

Cord-tissue derived MSCs are universally accepted, there is no need for HLA donor matching.

Seven Mile Beach, Grand Cayman

Discover the Cayman Islands

Grand Cayman is not just one of the world's top medical tourism destinations. The Cayman Islands also has some of the world's best beaches, five-star resorts, and world-class dining experiences. There is more to Cayman than meets the eye!

FDA registered & cGMP compliant lab
stem cell lab technician
mesenchymal stem cell

We offer the highest quality mesenchymal stem cells in the world - sourced from a cGMP quality lab in the United States.

Our cell product:

300 Million MSCs Administered

We administer a minimum of 300 million mesenchymal stem cells derived from ethically sourced, AATB certified umbilical cord tissue.

cGMP Quality Cells

Adherence to the cGMP regulations assures the identity, strength, quality, and purity of our mesenchymal stem cell (MSC) product by requiring that our partner lab adequately controls manufacturing operations.

Viability Testing Conducted

Cell viability assays are used to measure the physical and physiological health of cells in response to extracellular stimuli and ensure every patient receives the same dosage (300m MSCs).

Cell viability refers to the number of live, healthy cells in a sample.

COA Authenticity

A Certificate of Analysis (COA) is a document that communicates the results of scientific tests done on the cells prior to infusion. The COA is created to ensure all important regulations are met and complied with. This allows us to ensure the safety of the cell product prior to infusion.

ISCT Approved

International Society for Cell & Gene Therapies (ISCT) is the global leader focused on translational aspects of developing cell-based therapeutics, advancing scientific research into innovative treatments for patients. The ISCT definition dictates that MSCs should have ≥95% surface marker expression, which we strictly follow.

Clinic Location

Our Facility

DVC Stem is located on Seven Mile Beach in Grand Cayman, a small island paradise in the Caribbean. The Cayman Islands is an English-speaking British Overseas Territory and hosts over 2 million tourists a year. There are many direct flights to Grand Cayman from major cities in the U.S. and Europe. DVC Stem is located within the Da Vinci Centre a large modern medical facility directly on Seven Mile Beach.

Discover Paradise

The largest of the three Cayman Islands, this Caribbean oasis sets the bar high when it comes to safe, luxurious travel with stunning artistic, culinary and natural experiences. Untouched natural beachfront, beautiful heritage sites, and mystical marine encounters number among many extraordinary things to do in the Cayman Islands. Or just sit back and relax at one of the 5-star resorts on Seven Mile Beach with a healthy green juice and your favorite fantasy novel.

Learn more about the beauty of the Cayman Islands here.

Accommodation

DVC Stem patients have the ability to access preferred pricing for partner resorts, The Westin, & Ritz Carlton. We also offer packages that include airport transfer, acomodation and transportation to and from our facility. Learn more about accommodation packages on our pricing page.

Post-treatment

Treatment Results

Treatment results are quantified by measuring changes in unique inflammatory markers in conjunction with subjective data provided in PAR-Q vitality questionnaires.

Patient response to treatment is dependent on a large variety of biological factors, however is also subject to the behavior and lifestyle of the patient. Patients who adhere to an active lifestyle, anti-inflammatory diet, and restrict the consumption of alcohol, tobacco, and caffeine can seen sustained results for 2+ years, depending on condition.

On average, patients have reported little signs of regression up to 24 months following treatment and patients rarely return to their pre-treatment state.

As required by our IRB, our patient management team will follow-up with patients every 3 months for 24 months post-treatment in order to collect post-treatment efficacy data.

Preliminary Efficacy Data

We are currently still collecting long-term data and do not have any published results to share specifically related to our IRB-approved clinical trials. (Trial HPC/CTR/003).

However, preliminary data that has been collected over the past 4 years has been exciting. Patient reported results have since shown that ~87.5% of our total patient population have noted a sustained improvement in their condition within 3 months of treatment.

More specifically, the current average improvements for our patients 3 months after treatment are as follows:

75% increase in Stamina
53.75% increase in Libido
51.40% increase in Energy Levels
43.97% increase in Balance
28% increase in Coordination
23.19% increase in Strength
21% increase in Vision

Average improvements concerning cognitive function 12 months after treatment are as follows:

19.84% improvement in Memory
44% improvement in Ability to Concentrate
31.94% improvement in Decision Making
12.5% increase in Quality of Sleep

Expected Improvement Timeline

Treatment may produce measurable results within 3-6 months following treatment. This is indicated by a marked reduction in levels of inflammation and changes in general vitality as measure by our follow-up questionnaire.

However, it is common for patients to report improvements in their quality of life and a lessening of their symptoms within the first few weeks following treatment. However, every patient is unique and may respond to treatment differently.

Trusted by hundreds of patients worldwide

We only offer treatments for conditions that have medical research backing positive results and no harmful side effects. Hundreds of studies have shown the safety and efficacy of stem cell therapies for various degenerative diseases. View some of our most notable patient testimonials below or you can view all patient testimonials here.

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"It has been 4 weeks since my treatment.  At present I have not gone further downhill and have shown some minor improvement.  This is a major accomplishment for an ALS patient."

Charles W.

ALS
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"The treatment was absolutely amazing. Dr. Cona talked me through the whole procedure and kept me relaxed the entire time."

Eddie Hall

Chronic Inflammation / Intelligent Aging
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"From the moment I went into the clinic to receive stem cells I felt like I was with family. I have never met such sincere devoted medical people in my life."

Janice G.

COPD
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"Less pain in my feet. Less stiffness in the morning. Less fatigued."

Chandra M.

Rheumatoid Arthritis
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They treated me like family and tended to anything we needed throughout the whole process. I am beyond grateful for everything and I can not recommend them all enough.

Maria A.

Multiple Sclerosis / Neuropathy
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"I have been able to cut my spasticity meds in half as I have less spasms, tremors, and stiffness in many areas of my body."

Debbie P.

Multiple Sclerosis
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"I decided to try DVC stem cell clinic . For me it was an absolute miracle the cough quickly went away and I could breathe normally within two weeks plus I felt fantastic."

Ron A.

Asbestosis
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"Dr. Cona and his staff were wonderful, they went above and beyond to accommodate us and make us feel at home while in office for treatment. We are so thankful for Dr. Cona and this stem cell treatment! Thank you!"

Douglas A.

Stroke Recovery
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"For us, stem cells were actually a cheaper option than the Dr. recommended MS therapies. Since the very next day, we have seen improvements in gait, balance, energy and stress.  These are all huge because gait and balance improvements are helping him to avoid falls."

Michael M.

Multiple Sclerosis
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"I have noticed that my speech seems to be better not quite as much stuttering I feel that my left side doesn’t drag when I walk hardly at all now my shaking in my hand left side is maybe a little bit worse than three months ago"

Darren J.

Parkinson's Disease
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"Amazing difference thank you very much.
I have my life back"

Dalton H.

Lyme Disease
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"I saw a substantial increase in energy levels, strength, coordination, balance and motivation up to four weeks after treatment. My physical therapist remarked on how well I was walking. My right leg was moving just like my left leg without any spasticity or hitch in my step.

Kerri L.

Multiple Sclerosis
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"Less choking. His speaking is clearer and stronger. Able to eat more variety of foods. Drinking and swallowing has improved. Less muscle stiffness. Less cramps and tremors. Balance has improved and walking has improved. Have not shown any signs of decline in health."

Richard M.

ALS
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"Less pain. More mobility"

Walter A.

Intelligent Aging
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"Uncontrolled crying since 2017 stroke completely resolved in first week. Anemia improved within one month. Wheezing resolved within one month. Chills greatly improved within one month.

Susan A.

Kidney Disease
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"Lost Neuropathy in left foot and leg stopped taking inhaler and asthma pills also able to breathe and not be winded going up steps. I also stop taken medication for Acid reflex."

Michael B.

Type 1 Diabetes
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"Flexibility and range of motion in lower back and left shoulder/neck area has improved significantly. Energy level is consistently high and balance has increased dramatically. No blood test to date, but results to follow."

Ann W.

Liver Disease
FDA registered & cGMP compliant lab
stem cell lab technician
mesenchymal stem cell

We offer the highest quality mesenchymal stem cells in the world - sourced from a cGMP quality lab in the United States.

Our cell product:

300 Million MSCs Administered

We administer a minimum of 300 million mesenchymal stem cells derived from ethically sourced, AATB certified umbilical cord tissue.

cGMP Quality Cells

Adherence to the cGMP regulations assures the identity, strength, quality, and purity of our mesenchymal stem cell (MSC) product by requiring that our partner lab adequately controls manufacturing operations.

Viability Testing Conducted

Cell viability assays are used to measure the physical and physiological health of cells in response to extracellular stimuli and ensure every patient receives the same dosage (300m MSCs).

Cell viability refers to the number of live, healthy cells in a sample.

COA Authenticity

A Certificate of Analysis (COA) is a document that communicates the results of scientific tests done on the cells prior to infusion. The COA is created to ensure all important regulations are met and complied with. This allows us to ensure the safety of the cell product prior to infusion.

ISCT Approved

International Society for Cell & Gene Therapies (ISCT) is the global leader focused on translational aspects of developing cell-based therapeutics, advancing scientific research into innovative treatments for patients. The ISCT definition dictates that MSCs should have ≥95% surface marker expression, which we strictly follow.

Onboarding Process

Step 1: Complete Screening Application

A brief online screening application used to determine candidacy for our IRB-approved mesenchymal stem cell protocol. This pre-approval does not guarantee eligibility for treatment, only the ability to continue the onboarding process. Begin the onboarding process here.

Step 2: Complete Intake Forms

If the screening application is approved, you will receive Intake Forms and Prerequisites via email, both of which need to be completed prior to final clearance. The Intake Forms can be completed online using any PDF editor or printed and scanned back to us. All material can be sent directly to our email or fax number.

Step 3: Complete Prerequisites

Prior to final clearance, we require specific medical history documents, exams, imaging and labs to be submitted. The material should be provided by your primary care physician or specialist.  We can provide a requisition that will cover the required labs for patients in the US, Canada, and UK. We have partnerships with LabCorp, Dynacare & Blue Horizon Medical.

Our patient management team will work with you to make sure you have completed all of the required documents.

Once all material has been submitted, your package will be reviewed by our medical team and final treatment clearance may be granted. In certain cases, additional documentation may be requested before clearance can be issued.

Step 4: Schedule a Treatment Date

Once your package is approved, our patient management team will provide available treatment dates. (lead time is roughly 1 month)

Things to note:
50% deposit is required to schedule a treatment date.The remaining balance is due no later than 2 weeks prior to treatment.

How to submit payment:
An invoice will be provided via email by our patient management team with specific payment instructions.Payment can be made either over the phone (1 877 382 7836) or via cc authorization form.We accept Debit, Visa,Mastercard, Bank/Wire Transfers and Advance Care Card.

Learn more about our pricing structure on our pricing page.

IRB-approved protocol

Ready to get started?

Begin the patient on-boarding process and find out if you are a candidate for treatment.