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Stem Cell Therapy for Multiple Sclerosis (MS)

Louis A. Cona M.D.

Oct 18, 2019

Stem cell treatment for MS has demonstrated healing and repair-promoting properties. The use of expanded cord tissue-derived umbilical cord cells have made it possible to potentially treat MS more effectively.

What is Multiple Sclerosis (MS)?

Multiple Sclerosis (MS) is a chronic disease that causes issues with vision, balance, coordination, muscle control and other basic body functions. Multiple Sclerosis (MS) can affect your brain, spinal cord, and optic nerves in your eyes.

The effects are different for each person, some have mild symptoms while others may have quite severe symptoms that can prevent them from completing daily tasks.

MS is induced by an autoimmune issue that causes the patient's immune system to attack the myelin sheath, a fatty material that surrounds the nerve fibers to protect them. Without this protective outer layer, the nerve cells become vulnerable to damage, resulting in scar tissue. This damage prevents the brain from sending signals throughout the body resulting in a loss of strength, control, and sensation.

As a result, people experience symptoms such as:

  • Pain
  • Depression
  • Fatigue
  • Trouble walking
  • Blurred vision
  • Numbness or tingling
  • Drop foot
  • Muscle weakness or spasms

What age group is typically affected by Multiple Sclerosis (MS)?

Multiple Sclerosis (MS) Symptoms typically start between the ages of 20 and 40 years old. People can have relapses (periods of worsening symptoms) and periods of recovery where symptoms feel as if they are getting better. For most people, as the disease progresses, symptoms will get worse over time. There have been promising studies showing the efficacy of stem cell therapy and its ability to improve symptoms and even halt disease progression. (This will be explained further below)

What causes Multiple Sclerosis (MS)?

Scientists still do not know exactly what causes Multiple Sclerosis (MS), but several factors seem to make the disease more likely, including; smoking and certain genetic factors. Certain viral infections such as Epstein-Barr virus or the human herpesvirus 6 which both have immunosuppressive properties may also trigger the disease or cause a relapse. Scientists are currently studying the link between viruses and Multiple Sclerosis (MS) but have yet to publish any conclusive data confirming the link.

Is there a cure for Multiple Sclerosis (MS)?

Currently, there is no cure for Multiple Sclerosis (MS) but there are several treatments that can be prescribed that can manage the symptoms of MS. Unfortunately these treatments can be quite expensive and can reach upwards of $100,000 a year for the newest MS drugs.

Stem cell treatment for MS

Stem cell treatment for MS has demonstrated healing and repair-promoting properties. The use of expanded cord tissue-derived umbilical cord cells have made it possible to potentially treat MS more effectively. Mesenchymal stem cells (MSCs) can combat inflammation within the body. Once administered stem cells will work to repair and replace myelin as damage occurs (stem cell replacement). This makes Mesenchymal stem cells MSCs an attractive potential therapy for MS and other conditions characterized by inflammation and/or tissue injury. Mesenchymal stem cells (MSCs) represent an attractive alternative to develop a cell-based therapy for Multiple Sclerosis.


Stem cells and MS

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with a strong degenerative component, leading to irreversible disability. Mesenchymal stem cells (MSCs) have been shown to prevent inflammation and neurodegeneration in MS.

"Mesenchymal stem cells (MSC) are stromal [precursor] cells residing in many tissues, including the bone marrow (BM), where they support hematopoiesis. Treatment with MSC improves the course of the preclinical model of MS, experimental autoimmune encephalomyelitis (EAE) when administered at early stages. In EAE, MSC has a profound anti-inflammatory and immune-modulating effect [59], but they also exhibit neuroprotective features and foster remyelination endogenous neurogenesis with scarce evidence of differentiation in neural cells" - Antonio Uccelli

Mesenchymal stem cells (MSCs), have immune regulatory properties that may have the ability to prevent the immune system from attacking the myelin sheath surrounding nerve fibers. Mesenchymal stem (MScs) cells may have the ability to regenerate scar tissue (damaged myelin sheath) of the affected neurons. (also called remyelination) .

Stem cell replacement to help Multiple Sclerosis (MS)

Currently, the adult stem cells that are used at DVC Stem are sourced from ethically donated full-term human umbilical cord tissue. (allogeneic mesenchymal). The tissue is only sourced from the American Association of Tissue Banks (AATB) and cultured and expanded in our FDA 351 & 361 compliant, IRB approved, partner lab Vitro Biopharma, located in Golden Colorado, USA. This is to ensure that all human umbilical cord tissue is screened and tested for infectious disease as well as make sure the expansion process of the cells follows US safety standards.

Stem cell Multiple Sclerosis (MS) treatment advantages

  • Growing amount of evidence supporting the ability of mesenchymal stem cells to help regulate the immune system
  • Ability to repair damaged myelin sheath (remyelination) or neurons
  • Umbilical cord tissue provides a high number of mesenchymal cells
  • Stem cells are extremely anti-inflammatory allowing for the repair and regeneration of tissue
  • IV stem cell therapy is NOT invasive and does not require any downtime

Are stem cells safe?

Cord-tissue derived mesenchymal stem cells do not have any risk of rejection within the body. They are youthful, immune-privileged, undifferentiated cells that have no rejection in the body because they have yet to be “claimed”. There are no blood products associated with them either, removing the need for a donor match, they are universally accepted. These cells simply seek out inflammation in the body and begin to heal the damaged tissue. Mesenchymal cord tissue-derived stem cells have been administered thousands of times at clinics around the world and there has never been a single instance of rejection (graft vs. host disease).

Benefits of stem cell therapy for MS

​Other potential advantages of stem cell therapy for people with MS include their ability to move from the bloodstream to areas of injured tissues, allowing for a comfortable IV administration of these cells into the body. The stem cells will then be attracted to those areas of injury or inflammation and begin the process of differentiation to begin the healing process. Stem cell transplants for MS are generally less invasive, have shorter recovery times, and lasting healing effects on the body.

Want to learn more about stem cell therapy for MS at DVC Stem?

DVC Stem is a stem cell therapy pioneer, offering stem cell therapies for years and has become a cornerstone of the medical tourism industry. Located in the tropical paradise of Grand Cayman in the Western Caribbean, we offer patients a nearby alternative to traveling long distances and to less ideal locations. Our protocols are IRB approved, and our cells come from regulated, U.S. based, FDA compliant laboratories. We seek to offer the highest quality products, the latest available treatments for a variety of conditions, all combined with a world-class setting and service. We administer over 300 million cord tissue-derived mesenchymal stem cells via IV, our treatments are minimally invasive and we offer interest-free financing for US residents.

Apply for treatment here

3 DAYS POST TREATMENT

Tyler explains his experience at DVC Stem in the Cayman Islands.

Tyler is optimistic that he will see positive results post treatment.

"The cool thing about the Cayman Islands besides being beautiful, it was an opportunity to get some rest and relaxation allowing my body to heal and restore. I'm back in the US now and feel like I am ready to conquer the world."

- Tyler Heid

2 WEEKS POST TREATMENT

2 weeks post treatment, MS patient Tyler is beginning to see amazing progress. He has been wheelchair bound for the last year and has not been able to move his legs unassisted before now.

Tyler Heid, lifting his foot 12" off the ground with 2 lb weights on his ankles.

Tyler - 2 weeks post treatment

"I'm on a path of progression and I'm getting better and better each day."

Tyler Heid - 2 months post treatment

2 MONTHS POST TREATMENT

Tyler updates about his progress, explaining the amazing response he has been receiving from his friends and family.

"People coming up to me saying I am moving, talking and smiling so much better. They are noticing a lot of things that have improved over the course of 3 months."

"This morning I was able to do things that I was unable to do before, I was able to stand up and lift my leg higher than I ever have before."

5 MONTHS POST TREATMENT

5 months post treatment Tyler sends us an update on his progress.

"I'm able to smile better, I have more control over the left side of my face."

"I have an increased ability to grip, lift my legs higher and higher which has gone well."

Tyler is optimistic and on the right track to recovery. We are ecstatic to see his progress and look forward to more updates from him.

"I have an increased ability to grip, lift my legs higher and higher which has gone well."

Tyler Heid - 5 months post treatment

"This is exciting stuff, god bless"

Matthew Murry - MS Patient

2 WEEKS POST TREATMENT

Matthew experiences sensation in the bottom of his feet after receiving a simple nerve test.

His left foot did not experience any sensation or move at all, but what happened to his right foot is extremely exciting!

David Lyons

Multiple Sclerosis

Although David Lyons was able to successfully fight Multiple Sclerosis through a strict regimen of diet and exercise, he wanted to ensure he was doing everything he could to stay fit. Multiple Sclerosis can be managed with treatment, but there is currently no cure for the disease. For that reason, David came to DVC Stem years ago to use the regenerative and anti-inflammatory attributes of stem cells to aid in his fight for fitness.

The positive results he experienced enabled David to stay strong in the gym, now into his 60s, and that is why he continues to support our clinic to this day.

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