Louis A. Cona M.D.
Nov 6, 2019
Explaining the relationship between stem cells and Alzheimer's.
Alzheimer's Disease is the most common cause of dementia, categorized by a steep decline in one's ability to recall memory, think clearly and ultimately function independently. Alzheimer's disease is a degenerative condition that results in the loss of brain cells. Generally, Alzheimer's is associated with memory loss and the loss of simple cognitive abilities, impairing one's ability to complete daily tasks. Alzheimer's Disease accounts for between 60%-80% of dementia cases worldwide. The condition usually affects people over the age of 60, but it has been seen in patients as young as 30-40 years old. According to the Alzheimer's Association, "Alzheimer's is the sixth-leading cause of death in the United States. On average, a person with Alzheimer's lives four to eight years after diagnosis, but can live as long as 20 years, depending on other factors."
The symptoms of Alzheimer's Disease can become much more debilitating than simple memory loss. According to the Mayo Clinic people with Alzheimer's may:
These symptoms can greatly impair one's ability to function at work or even at home, resulting in a loss of independence or self-sufficiency.
Alzheimer's is thought to be caused by a combination of genetic, lifestyle and environmental factors. The exact cause of the disease is currently unknown, but scientists do know that the onset of Alzheimer's coincides with the brain's inability to function normally. This is followed by an increase in amyloid and tau protein buildup within the brain, though this is a symptom of Alzheimer's it has not been proven to be the cause of the disease.
Currently, there is no cure for Alzheimer's, although the condition is manageable to a certain degree with the proper treatments. Although these current treatments cannot stop the disease from progressing, it can slow the progression down as well as combat symptoms & improve quality of life.
Stem cell therapy is a unique approach to treating Alzheimer's Disease. It involved the systemic introduction of Mesenchymal Stem Cells into the body via IV. When introduced in large quantities these stem cells can find inflammation within the body and repair it. This unique property of stem cells is what potentially makes them a viable treatment for Alzheimer's Disease. According to Lawrence Goldstein, Ph.D., The increased amount of plaques and tangles within the brain of an Alzheimer's patient affect two essential proteins: ‘amyloid-beta’ and ‘tau’. Stem cell treatments target to replace the damaged cells with healthy stem cells which can grow on their own, hence, creating new healthy brain cells.
Mesenchymal Stem Cells (MSCs) or stromal stem cells can differentiate into many different types of cells within the body, including bone cells, cartilage, muscle cells, and even neural cells. They are largely found in the bone marrow of every person and remain dormant until called upon to promote healing within the body. They age as we age, and their number and effectiveness decreases over the years. By sourcing mesenchymal stem cells (MSCs) from donated cord tissue and expanding them to greater numbers, the medical community has created the ability to supplement a person’s stem cell count through transplantation with younger, highly effective cells.
According to Sung S. Choi and colleagues in a 2014 study titled Alzheimer's Disease and Stem Cell Therapy
"Stem cells have therapeutic effects using regeneration and substitution of cells and tissues themselves. The therapeutic strategy of stem cells has two directions. One is to induce the activation of endogenous stem cell and the other is to regenerate the injured cell or tissues through stem cell transplantation"
Choi continues to state that the transplantation of stem cells been able to improve functional recovery for Alzheimer's disease. Mesenchymal Stem Cells (MSCs) could promote survival, increased metabolic activity and help to rescue the AD cell model in vitro. He also states that the transplantation of MSCs has been able to reduce Aβ deposition, to improved memory and to alleviate the AD pathology in AD mouse models. What makes stem cell therapy for Alzheimer's so exciting is its possibility to halt the progression of the disease as well as regenerate damaged neurons rather than just slowing it, or managing symptoms.
If you would like to learn more about stem cell therapy for Alzheimer's Disease you can apply for treatment here: www.dvcstem.com/apply . We ask that you provide a brief description of your specific condition so we will be able to determine your candidacy for treatment.
Are you a candidate?
Complete our online application form to find out if you qualify for stem cell therapy.APPLY FOR TREATMENT
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