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Stem Cell Therapy for Alzheimer's

Louis A. Cona M.D.

Nov 6, 2019

Explaining the relationship between stem cells and Alzheimer's.

What is Alzheimer's?

Alzheimer's Disease is the most common cause of dementia, categorized by a steep decline in one's ability to recall memory, think clearly and ultimately function independently. Alzheimer's disease is a degenerative condition that results in the loss of brain cells. Generally, Alzheimer's is associated with memory loss and the loss of simple cognitive abilities, impairing one's ability to complete daily tasks. Alzheimer's Disease accounts for between 60%-80% of dementia cases worldwide. The condition usually affects people over the age of 60, but it has been seen in patients as young as 30-40 years old. According to the Alzheimer's Association, "Alzheimer's is the sixth-leading cause of death in the United States. On average, a person with Alzheimer's lives four to eight years after diagnosis, but can live as long as 20 years, depending on other factors."

Symptoms of Alzheimer's Disease

The symptoms of Alzheimer's Disease can become much more debilitating than simple memory loss. According to the Mayo Clinic people with Alzheimer's may:

  • Forget conversations, appointments, names, etc.
  • Get lost easier, lose their sense of direction
  • Have difficulty finding the correct word to associate with a familiar object
  • Repeat questions and statements
  • Eventually, forget the names of friends and family members
  • Changes in personality or behavior

These symptoms can greatly impair one's ability to function at work or even at home, resulting in a loss of independence or self-sufficiency.

Causes of Alzheimer's Disease

Alzheimer's is thought to be caused by a combination of genetic, lifestyle and environmental factors. The exact cause of the disease is currently unknown, but scientists do know that the onset of Alzheimer's coincides with the brain's inability to function normally. This is followed by an increase in amyloid and tau protein buildup within the brain, though this is a symptom of Alzheimer's it has not been proven to be the cause of the disease.

Stem cell therapy for alzheimer's
Pictured: Alzheimer's in the brain, a buildup of Amyloid Plaques.

Is there a cure for Alzheimer's Disease?

Currently, there is no cure for Alzheimer's, although the condition is manageable to a certain degree with the proper treatments. Although these current treatments cannot stop the disease from progressing, it can slow the progression down as well as combat symptoms & improve quality of life.

Stem Cell Therapy for Alzheimer's Disease

Stem cell therapy is a unique approach to treating Alzheimer's Disease. It involved the systemic introduction of Mesenchymal Stem Cells into the body via IV. When introduced in large quantities these stem cells can find inflammation within the body and repair it. This unique property of stem cells is what potentially makes them a viable treatment for Alzheimer's Disease. According to Lawrence Goldstein, Ph.D., The increased amount of plaques and tangles within the brain of an Alzheimer's patient affect two essential proteins: ‘amyloid-beta’ and ‘tau’. Stem cell treatments target to replace the damaged cells with healthy stem cells which can grow on their own, hence, creating new healthy brain cells.

Mesenchymal Stem Cells (MSCs) or stromal stem cells can differentiate into many different types of cells within the body, including bone cells, cartilage, muscle cells, and even neural cells. They are largely found in the bone marrow of every person and remain dormant until called upon to promote healing within the body. They age as we age, and their number and effectiveness decreases over the years. By sourcing mesenchymal stem cells (MSCs) from donated cord tissue and expanding them to greater numbers, the medical community has created the ability to supplement a person’s stem cell count through transplantation with younger, highly effective cells.

According to Sung S. Choi and colleagues in a 2014 study titled Alzheimer's Disease and Stem Cell Therapy 

"Stem cells have therapeutic effects using regeneration and substitution of cells and tissues themselves. The therapeutic strategy of stem cells has two directions. One is to induce the activation of endogenous stem cell and the other is to regenerate the injured cell or tissues through stem cell transplantation"

Choi continues to state that the transplantation of stem cells been able to improve functional recovery for Alzheimer's disease. Mesenchymal Stem Cells (MSCs) could promote survival, increased metabolic activity and help to rescue the AD cell model in vitro. He also states that the transplantation of MSCs has been able to reduce Aβ deposition, to improved memory and to alleviate the AD pathology in AD mouse models. What makes stem cell therapy for Alzheimer's so exciting is its possibility to halt the progression of the disease as well as regenerate damaged neurons rather than just slowing it, or managing symptoms.

If you would like to learn more about stem cell therapy for Alzheimer's Disease you can apply for treatment here: www.dvcstem.com/apply . We ask that you provide a brief description of your specific condition so we will be able to determine your candidacy for treatment.

3 DAYS POST TREATMENT

Tyler explains his experience at DVC Stem in the Cayman Islands.

Tyler is optimistic that he will see positive results post treatment.

"The cool thing about the Cayman Islands besides being beautiful, it was an opportunity to get some rest and relaxation allowing my body to heal and restore. I'm back in the US now and feel like I am ready to conquer the world."

- Tyler Heid

2 WEEKS POST TREATMENT

2 weeks post treatment, MS patient Tyler is beginning to see amazing progress. He has been wheelchair bound for the last year and has not been able to move his legs unassisted before now.

Tyler Heid, lifting his foot 12" off the ground with 2 lb weights on his ankles.

Tyler - 2 weeks post treatment

"I'm on a path of progression and I'm getting better and better each day."

Tyler Heid - 2 months post treatment

2 MONTHS POST TREATMENT

Tyler updates about his progress, explaining the amazing response he has been receiving from his friends and family.

"People coming up to me saying I am moving, talking and smiling so much better. They are noticing a lot of things that have improved over the course of 3 months."

"This morning I was able to do things that I was unable to do before, I was able to stand up and lift my leg higher than I ever have before."

5 MONTHS POST TREATMENT

5 months post treatment Tyler sends us an update on his progress.

"I'm able to smile better, I have more control over the left side of my face."

"I have an increased ability to grip, lift my legs higher and higher which has gone well."

Tyler is optimistic and on the right track to recovery. We are ecstatic to see his progress and look forward to more updates from him.

"I have an increased ability to grip, lift my legs higher and higher which has gone well."

Tyler Heid - 5 months post treatment

"This is exciting stuff, god bless"

Matthew Murry - MS Patient

2 WEEKS POST TREATMENT

Matthew experiences sensation in the bottom of his feet after receiving a simple nerve test.

His left foot did not experience any sensation or move at all, but what happened to his right foot is extremely exciting!

David Lyons

Multiple Sclerosis

Although David Lyons was able to successfully fight Multiple Sclerosis through a strict regimen of diet and exercise, he wanted to ensure he was doing everything he could to stay fit. Multiple Sclerosis can be managed with treatment, but there is currently no cure for the disease. For that reason, David came to DVC Stem years ago to use the regenerative and anti-inflammatory attributes of stem cells to aid in his fight for fitness.

The positive results he experienced enabled David to stay strong in the gym, now into his 60s, and that is why he continues to support our clinic to this day.

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