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What are Exosomes?

Exosomes are particles that release naturally from a cell. These particles are responsible for cell to cell communication. These messenger cells have the ability to release growth factors and other beneficial processes.

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David Lyons

Guest contributor

Feb 12, 2020

Louis A. Cona, MD

Medical Director of DVC Stem

Stem cell therapy clinic in Grand Cayman

Updated:

Wednesday, February 12, 2020

Exosome therapy is gaining popularity in the field of regenerative medicine. So what are exosomes? Are they a viable treatment option? How are exosomes related to stem cells?

What are Exosomes?

Exosomes are extracellular vesicles (particles that release naturally from a cell that cannot replicate) that are responsible for cell to cell communication. Exosomes are released naturally from cells upon the fusion of a discontinuous closed membrane system, also known as the intermediate endocytic compartment. Although exosomes are roughly the same size (40-100 nm) as ectosomes, they are different species of vesicles.


Exosome cell communication diagram
Exosome cell communication diagram

What is exosome therapy?

Exosome therapy is gaining in popularity within the United States. Some doctors believe there may be benefits with the administration of exosomes, but there is minimal data proving safety and efficacy. This theory may have originated from studies that suggest the link between the health benefits of mesenchymal stem cells and exosomes. Exosomes are released naturally from mesenchymal stem cells, and MSCs have the highest amount of exosomes out of any cell. These studies (outlined below) argue that exosomes may have therapeutic abilities, but researchers have found no conclusive evidence. There is also a regulatory concern about the legality of such treatments, especially when the exosome preparation protocol involves extraction from MSCs.


Why the increased interest in Exosome therapy?

According to James R Edgar,

“This could be due to three reasons. Firstly, exosomes are thought to provide a means of intercellular communication and transmission of macromolecules between cells. Second, in the past decade, exosomes have been attributed roles in the spread of proteins, lipids, mRNA, miRNA, and DNA and as contributing factors in the development of several diseases. Thirdly, exosomes have been proposed to be useful vectors for drugs because they are composed of cell membranes rather than synthetic polymers, and as such, could be better tolerated by the host.” (1)

Exosomes and stem cells

Mesenchymal stem cells (MSCs) can self-renew and can be isolated from various tissues. They have been tested widely in clinical trials due to their multitude of biological functions, including; differentiation, tissue repair, anti-inflammatory, and immunomodulatory properties.

Exosomes derived from mesenchymal stem cells (MSCs), first investigated in a 2010 finding, showed that MSCs were able to produce higher amounts of exosomes than other cells. (2)

According to Zhang, exosomes are involved in cell to cell communication, and some researchers hypothesize that they are the paracrine effectors of MSCs. 

Many types of cells secrete exosomes, including T and B cells, cancer cells, and stem cells. Although Exosomes are essential for cellular communication, their functions remain unknown.

Image of B cell and exosomes

Exosome MSCs

Mesenchymal stem cells may have the ability to repair tissue, modulate the immune system, and promote an anti-inflammatory response in patients. In an article published in the International Journal of Molecular Sciences, Zhang et al. state that “Several studies have reported that exosomes have functions similar to MSCs; however, the mechanisms are still not fully understood and remain controversial.” (2)

“Given the merits of MSCs, exosomes hold great promise as a controllable, manageable, and feasible approach in future studies. However, based on the proteomic and genomic complexities of exosomes, their possible mechanisms and exact compositions need further investigation.”



Mesenchymal stem cells can produce prolific amounts of exosomes. Exosomes derived from mesenchymal stem cells have the potential to be used as a vehicle for drug or gene delivery or to facilitate cell therapy. (2) The study concluded that exosomes hold promise, but more studies are required before being able to consider using exosomes alone as a potential treatment option.

Exosomes and anti-aging

Clinics in the United States are hailing exosome therapy for anti-aging as a new miracle cure. Some of these entities state that exosomes are more potent than MSCs at combating certain conditions. There are a few issues with these claims; firstly, there is a lack of data supporting the efficacy of exosomes without also introducing MSCs into the patient. Secondly, there are regulation concerns with exosomes in the United States that may promote the use of exosomes as a way of offering cell therapy while avoiding legal limitations set forth from the FDA. While there could potentially be some benefits with exosomes, they are still mostly understudied and unknown.

Exosome therapy and the FDA

Treatment with expanded MSCs is primarily not authorized by the FDA in the United States. These cells require approval from the FDA and require an Investigational New Drug Application (IND) submission. These regulations directly correlate with the rise in the popularity of exosome therapies. The regulatory environment in the United States and the disparity between different therapeutics can benefit clinics that market and administer exosomes because it may be easier to bypass the 4th criterion of 361 HCT/P’ S.


Conclusion

Exosome therapy may eventually have a place in the regenerative medicine sphere, but for now, it seems as though the development of using exosomes for treatment is still in its early stages. It is vital to have reliable data from clinical studies in human subjects that can prove that these exosome products functionally work.


DVC Stem

DVC Stem is a stem cell therapy pioneer, offering stem cell therapies for years and has become a cornerstone of the medical tourism industry. Located in the tropical paradise of Grand Cayman in the Western Caribbean, we offer patients a nearby alternative to traveling long distances and to less ideal locations. Our protocols are IRB approved, and our cells come from regulated, U.S. based, FDA compliant laboratories. We seek to offer the highest quality products, the latest available treatments for a variety of conditions, all combined with a world-class setting and service. We offer treatment that includes the intravenous administration of over 300 million cord tissue-derived mesenchymal stem cells.

References

  1. Edgar, James R. “Q&A: What Are Exosomes, Exactly?” BMC Biology, BioMed Central, 13 June 2016, https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0268-z.
  2. Yu, Bo, et al. “Exosomes Derived from Mesenchymal Stem Cells.” International Journal of Molecular Sciences, vol. 15, no. 3, July 2014, pp. 4142–4157., doi:10.3390/ijms15034142.

"Dr. Cona is a leading edge stem cell treatment physician"

Matthew Murry - MS Patient

2 DAYS POST TREATMENT

"Is the video I posted from this morning! My speech is so easy for me now, got easier throughout the day! I can talk like a NYer (fast) for the first time in years! Praise God!"

- Matthew Murry

EXCITING IMPROVEMENTS

Only 3 days after treatment, Matthew is now able to touch his nose with his eyes closed as well as touch his thumb and pinky together. Both of which he was previously unable to do before treatment.

We are excited to see his continued progress. His story will be updated here so keep an eye out!

Matthew showing his progress with mobility

Matthew Murry - 3 days post treatment

"This is exciting stuff, god bless"

Matthew Murry - MS Patient

2 WEEKS POST TREATMENT

Matthew experiences sensation in the bottom of his feet after receiving a simple nerve test.

His left foot did not experience any sensation or move at all, but what happened to his right foot is extremely exciting!

50 DAYS POST TREATMENT

Matthew is now able to lift his leg unassisted. He was previously unable to do so.

Matthew is experiencing the benefits of stem cell therapy first hand. You can view his progress video here.


Matthew showing some amazing mobility improvements.

Matthew Murry - 50 days post treatment

"Amazing progress from one of our MS patients Matthew Murray"

Louis A. Cona, MD - DVC Stem

3 MONTHS POST TREATMENT

Matthew is able to stand up with the assistance of stability bars.

David Lyons

Multiple Sclerosis

Although David Lyons was able to successfully fight Multiple Sclerosis through a strict regimen of diet and exercise, he wanted to ensure he was doing everything he could to stay fit. Multiple Sclerosis can be managed with treatment, but there is currently no cure for the disease. For that reason, David came to DVC Stem years ago to use the regenerative and anti-inflammatory attributes of stem cells to aid in his fight for fitness.

The positive results he experienced enabled David to stay strong in the gym, now into his 60s, and that is why he continues to support our clinic to this day.

Are you a candidate?

Complete our online application form to find out if you qualify for stem cell therapy.

APPLY FOR TREATMENT

About Our Medical DIrector

Louis A. Cona, MD

LOUIS A. CONA, MD

Dr. Cona has been performing stem cell therapy for over 10 years. He is a member of the World Academy of Anti-Aging Medicine (WAAAM). He is also a recognized member of the British Medical Association, the General Medical Council (UK), the Caribbean College of Family Physicians, and the American Academy of Family Physicians. He is the Medical Director for DVC Stem a world-renowned stem cell therapy clinic located in Grand Cayman.

Are you a candidate?

Complete our online application form to find out if you qualify for stem cell therapy.

APPLY FOR TREATMENT

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