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Autologous or Allogeneic Stem Cells?

Reading time: 2 minutes 55 seconds

David Lyons

Guest contributor

Jun 2, 2020

Louis A. Cona, MD

Medical Director of DVC Stem

Stem cell therapy clinic in Grand Cayman

Updated:

Tuesday, June 2, 2020

Here we explain what HSCT is and how it differs from the type of therapy DVC Stem offers.


There are many forms of stem cell therapy, but the leading ones today are Autologous and Allogeneic treatments. While both aim at the same results, the methods used to achieve them are very different. With support growing behind each form of treatment in communities surrounding degenerative diseases and autoimmune disorders, it can be challenging to decide which path is best. It is essential to know the details behind each option and make the right choice. More importantly, it is vital to understand the risks and rewards associated with both.

What is an Autologous Stem Cell Transplant?

An Autologous Stem Cell Transplant is a transplantation in which stem cells are removed from a person, stored, and later given back to that same person.


Where do these stem cells originate?

Stem cells exist in everyone. We have a supply of youthful stem cells when we are born, but they are used for body repair as we age. Additionally, stem cell potency decreases as we age. The stem cells from a patient in their 60s will not act similarly to those from an infant. 


In autologous treatment, stem cells are extracted from a patient’s tissue, whether that be fat, bone marrow, or blood. 


The stem cells are then purified and expanded before being reintroduced into the body in a targeted manner to stimulate a healing response.


What is HSCT?

In a Hematopoietic Stem Cell Transplant (HSCT), following cell extraction, the patient is subjected to high doses of chemotherapy or radiation to kill or deactivate the immune system. 

The removed stem cells, having been unaffected by the chemotherapy, are then reintroduced to the body, helping it to begin producing healthy red and white blood cells once again. 


Is HSCT efficacious?

Results for Hematopoietic Stem Cell Transplants (HSCT) have been positive for autoimmune diseases, such as Multiple Sclerosis, in which the immune system attacks a patient’s body. The treatment “resets” the immune system, hoping to cease the effects of the disorder. However, many patients are turned off by the use of chemotherapy and the inherent risks associated with such aggressive treatment. Some patients may be in too poor a condition to even attempt this form of treatment. Although safety has dramatically improved with experience, HSCT initially had a 1 in 100 death rate for participants.

What is an Allogeneic Transplant? (Cord Tissue-Derived)

Allogeneic therapy similarly seeks to promote healing and repair within the body but in a much less invasive way. In this treatment form, stem cells are obtained from outside sources, such as donated umbilical cord tissue. 


Cord Tissue-Derived Mesenchymal Stem Cells

Cord tissue, or “Wharton’s Jelly,” has some of the most potent, primal stem cells that can be found. As previously mentioned, stem cells at the point of birth are at the peak of their potency, and umbilical cord tissue is often discarded after birth, making them widely available. Additionally, there is no immune response to cells sourced from cord tissue, negating the need for a matched donor for each patient.


Allogeneic Transplant Process

Stem cells are extracted from the source, then purified and expanded into the millions before being transplanted into a patient. The patient is prepared for treatment through a variety of methods and given stem cell activation supplements, vice chemotherapy. The principle is to allow the influx of new, healthy stem cells to travel the body through the bloodstream, where they can naturally seek out damage and inflammation to begin the repair process.


Allogeneic transplants are non-invasive

The tradeoff with allogeneic transplant is that it is a much less invasive and radical procedure, having little impact on the patient; however, the results are understandably milder than with Hematopoietic Stem Cell Transplants (HSCT). 

Allogeneic transplants give patients an option for effective treatment without the risk of chemotherapy, or who may be in too poor a condition to undergo HSCT. 

Additionally, the non-invasive nature of the procedure allows for repeat treatment over time without continuous damage being done to the body.

DVC Stem

DVC Stem is a stem cell therapy pioneer, offering stem cell therapies for years and has become a cornerstone of the medical tourism industry. Located in the tropical paradise of Grand Cayman in the Western Caribbean.

DVC Stem offers patients a nearby alternative to travelling long distances and to less ideal locations. Their protocols are IRB approved, and DVC’s cells come from regulated, U.S. based, FDA compliant laboratories. 

"Dr. Cona is a leading edge stem cell treatment physician"

Matthew Murry - MS Patient

2 DAYS POST TREATMENT

"Is the video I posted from this morning! My speech is so easy for me now, got easier throughout the day! I can talk like a NYer (fast) for the first time in years! Praise God!"

- Matthew Murry

EXCITING IMPROVEMENTS

Only 3 days after treatment, Matthew is now able to touch his nose with his eyes closed as well as touch his thumb and pinky together. Both of which he was previously unable to do before treatment.

We are excited to see his continued progress. His story will be updated here so keep an eye out!

Matthew showing his progress with mobility

Matthew Murry - 3 days post treatment

"This is exciting stuff, god bless"

Matthew Murry - MS Patient

2 WEEKS POST TREATMENT

Matthew experiences sensation in the bottom of his feet after receiving a simple nerve test.

His left foot did not experience any sensation or move at all, but what happened to his right foot is extremely exciting!

50 DAYS POST TREATMENT

Matthew is now able to lift his leg unassisted. He was previously unable to do so.

Matthew is experiencing the benefits of stem cell therapy first hand. You can view his progress video here.


Matthew showing some amazing mobility improvements.

Matthew Murry - 50 days post treatment

"Amazing progress from one of our MS patients Matthew Murray"

Louis A. Cona, MD - DVC Stem

3 MONTHS POST TREATMENT

Matthew is able to stand up with the assistance of stability bars.

David Lyons

Multiple Sclerosis

Although David Lyons was able to successfully fight Multiple Sclerosis through a strict regimen of diet and exercise, he wanted to ensure he was doing everything he could to stay fit. Multiple Sclerosis can be managed with treatment, but there is currently no cure for the disease. For that reason, David came to DVC Stem years ago to use the regenerative and anti-inflammatory attributes of stem cells to aid in his fight for fitness.

The positive results he experienced enabled David to stay strong in the gym, now into his 60s, and that is why he continues to support our clinic to this day.

Are you a candidate?

Complete our online application form to find out if you qualify for stem cell therapy.

APPLY FOR TREATMENT

About Our Medical DIrector

Louis A. Cona, MD

LOUIS A. CONA, MD

Dr. Cona has been performing stem cell therapy for over 10 years. He is a member of the World Academy of Anti-Aging Medicine (WAAAM). He is also a recognized member of the British Medical Association, the General Medical Council (UK), the Caribbean College of Family Physicians, and the American Academy of Family Physicians. He is the Medical Director for DVC Stem a world-renowned stem cell therapy clinic located in Grand Cayman.

Are you a candidate?

Complete our online application form to find out if you qualify for stem cell therapy.

APPLY FOR TREATMENT

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